17-P001 Bmp4 promotes differentiation of the first vertebrate epithelium

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

17-P001 Bmp4 promotes differentiation of the first vertebrate epithelium

A common feature of early vertebrate embryos is that they are surrounded by a simple protective epithelial cell layer. However, it is currently not well understood how the differentiation of this epithelium is controlled. We present data showing that BMP4 is sufficient to promote differentiation of this epithelium in diverse vertebrates. In mouse embryos the outer epithelium forms the trophecto...

متن کامل

MicroRNA-378 promotes myogenic differentiation by targeting BMP4.

MicroRNA-378 (miRNA-378) has been reported to have a crucial role in skeletal muscle differentiation; however, the underlying mechanisms have largely remained to be elucidated. The present study employed high‑throughput RNA sequencing to investigate the transcriptome following transfection of miRNA‑378 mimics or control RNAs into C2C12 myoblast cells. By sequencing and annotation, 2,802 transcr...

متن کامل

09-P001 Role of Flrt3 during vertebrate limb development

The apical ectodermal ridge (AER), a thickening of the limb epithelium at its distal tip, is pivotal for maintaining vertebrate limb outgrowth. In a recent study, Flrt3 has been involved in the activation of ERK by FGFs. Moreover, Flrt3 has been described as a transmembrane protein able to interact with FGF receptors modulating, this way, FGFR signaling, either directly or recruiting cytoplasmi...

متن کامل

The effect of BMP4 on mouse embryonic stem cell proliferation and differentiation into primordial germ cells

Background and Aim: Artificial gamete production from stem cells is a novel strategy for treatment of infertility. Among various stem cell sources, embryonic stem cells (ESC) can be considered as an appropriate source for in vitro formation of germ cells. In this study we evaluated the effect of BMP4 on proliferation and differentiation of mouse embryonic stem cells into primordial germ cells (...

متن کامل

BMP4 inhibits proliferation and promotes myocyte differentiation of lung fibroblasts via Smad1 and JNK pathways.

Fibroblast proliferation, differentiation, and migration contribute to the characteristic pulmonary vascular remodeling seen in primary pulmonary hypertension (PPH). The identification of mutations in the bone morphogenetic protein type II receptor (BMPRII) in PPH have led us to question what role BMPRII and its ligands play in pulmonary vascular remodeling. Thus, to further understand the func...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Mechanisms of Development

سال: 2009

ISSN: 0925-4773

DOI: 10.1016/j.mod.2009.06.722